After restraint stress, mice with high and low immobility time have a different neurochemical and behavioral profile

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Thiago Reis-Silva
Ana Paula Lima
Natalia Moreira
Atilio Calefi
Thaísa Meira Sandini
Jorge Camilo Florio
Maria Martha Bernardi

Resumo

High and low immobility on the tail suspension test is a common tool for assessing antidepressant drug effects. However, those parameters might be a natural phenotype present in the mice population and could be selected through behavior evaluation without an induced-drug behavior need. High immobility has been also related to depressed-like behavior, that in humans are characterized by wide range of symptoms, such as anhedonia, anxiety and tiredness. 

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Seção

SEMANA CIENTÍFICA PROF. DR. BENJAMIN EURICO MALUCELLI

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After restraint stress, mice with high and low immobility time have a different neurochemical and behavioral profile. Revista de Educação Continuada em Medicina Veterinária e Zootecnia do CRMV-SP, [S. l.], v. 14, n. 1, p. 57–57, 2016. Disponível em: https://www.revistamvez-crmvsp.com.br/index.php/recmvz/article/view/31107. Acesso em: 6 dez. 2025.