Feline injection-site sarcoma (FISS): literature review

Main Article Content

Raphael G. da Silva
Paulo Roberto Martin
Eduardo Fernandes Bondan

Abstract

This review study analyzed the etiopathogenesis, epidemiology, biological behavior, diagnosis, treatment, and prevention of feline injection-site sarcomas (FISS), malignant neoplasms associated with subcutaneous or intramuscular injection sites. Although the etiology is not fully understood, intense chronic inflammatory processes combined with mutations in tumor suppressor genes are believed to play a central role in its pathogenesis. Fibrosarcoma is the most common histological subtype, characterized by highly infiltrative behavior and a high rate of local recurrence, resulting in a guarded prognosis. Diagnosis is based on histopathological evaluation and imaging techniques to detect metastases and support therapeutic planning. Surgical excision is the primary treatment; however, when performed alone, it is associated with high recurrence rates and a median survival time of four to six months. Therefore, combining surgery with adjuvant therapies such as electrochemotherapy, chemotherapy, and radiotherapy is essential to improve tumor control and clinical outcomes.

Article Details

Section

MEDICINA VETERINÁRIA

Author Biographies

Raphael G. da Silva, Cruzeiro do Sul University

Doctor of Veterinary Medicine, master of Science, professor, Cruzeiro do Sul University, Department of Surgery, São Paulo, SP, Brazil.

Paulo Roberto Martin, Self-employed

Doctor of Veterinary Medicine, self-employed practitioner, specialist in Veterinary Surgery and Oncology, São Paulo, SP, Brazil.

Eduardo Fernandes Bondan, Cruzeiro do Sul University

Doctor of Veterinary Medicine, doctor of Philosophy, full professor, Cruzeiro do Sul University and Paulista University, department of Environmental and Experimental Pathology, São Paulo, SP, Brazil.

How to Cite

Feline injection-site sarcoma (FISS): literature review. Revista de Educação Continuada em Medicina Veterinária e Zootecnia, [S. l.], v. 24, n. esp. 1, 2026. DOI: 10.36440/recmvz.v24.38878. Disponível em: https://www.revistamvez-crmvsp.com.br/index.php/recmvz/article/view/38878. Acesso em: 14 mar. 2026.